A dog crossing Highway 44 caused a single vehicle accident near County Road 303, officials said.
A driver in a white Ford Focus was traveling eastbound on Highway 44 when a stray dog attempted to cross the road.
The 22-year-old Laredo woman tried to avoid the four-legged creature, lost control and hit a tree, according to Department of Public Safety Trooper Joe Abreu.
In the process the woman hit the animal.
All the occupants wore their seat belts or were in safety seats. According to troopers, they do not believe speed was a factor in the accident.
A 5-year-old girl was flown by Halo flight to Driscoll Children's Hospital in Corpus Christi with head trauma, according to DPS troopers at the scene.
The woman's 15-year-old son who was asleep in the back seat was transported to an Alice hospital with a possible broken leg.
The San Diego Police and Fire Department, the Duval County Sheriff's Department, the Freer Fire Department, and EMS from San Diego assisted in the morning accident.